IRON Quantification

Discover SPIN Iron
  • fast, easy to use and reliable software

  • automatic quantification of iron in midbrain and basal ganglia

  • single and multi echo acquisitions

  • simultaneous data acquisition and image processing algorithms

How does SPIN Iron work?

SPIN's Iron quantification approach is based on the use of quantitative susceptibility maps (the intensity of which is given in parts per billion) which is representative of, and proportional to, the concentration of iron in the tissue (1μg of Fe/g wet tissue is roughly equal to 1 ppb in the SWIM images). ​

Based on one of our papers, we used a large cohort of 174 healthy subjects to establish a robust baseline of iron content in seven basal ganglia and midbrain structures as a function of age. Global analysis (3D whole-structural) and regional analysis (i.e. pixel-wise high iron content region defined as susceptibility values higher than two standard deviations of the mean of global analysis) were evaluated. As a result, the regional analysis has shown a much tighter and sensitive linear age-related behavior in almost all structures. This novel method potentially allows the differentiation of normal from abnormal iron deposition providing the physicians with another quantitative metric which may be useful in understanding the etiology and treatment requirements for different neurodegenerative diseases.

Clinical use:
  • Multiple Sclerosis

  • Dementia

  • Parkinson's disease 

  • Huntington's disease

  • Normal aging

  • ​Cerebral Microbleed

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